Nutrient Cures

What Supplements Lower Histamine?

The purple flowers of a stinging nettle plant

What Supplements Lower Histamine?

There are many natural supplements that lower histamine. They work much like conventional antihistamines. Check with your doctor and try some of these great alternatives to pharmaceuticals. Some are mineral based while others are vitamin or plant based but they can all help allergy and histamine intolerance sufferers. Here are some of the best natural supplements to lower histamine:

  • Quercetin,
  • Vitamin C,
  • Nettle,
  • Zinc,
  • DAO Enzyme

So how does lowering histamine help allergy sufferers, how do these natural supplements work and what brands are best? We will address all those questions here.

How Can Lowering Histamine Help Allergies?

If you have histamine intolerance or allergies in general, you know that antihistamines can be a life saver. Bendryl, Allegra, Claritin and others are staples for allergy sufferers. High levels of histamine cause allergic symptoms such as running nose, sneezing, itching and symptoms of histamine intolerance which can include headaches, swelling, hives, asthma, irregular heartbeat, low blood pressure and digestive problems. In some people more histamines are released and allergies are more severe than others. This is part of the reason some people are allergic to certain foods like peanuts or shellfish and some are not. It is due to a difference in histamine release by the body. You can try to avoid allergy triggers but if you have many allergies this can be a huge challenge. People with histamine problems may be allergic to dozens of different substances including pollen, pets, foods and many chemicals.

It is often not possible to avoid all of our allergy triggers so it may be beneficial to find a way to address the histamine release itself rather than avoiding all the allergens. Conventional antihistamines help people with allergies be able to live a normal life but they come with side effects and it is never good to take prescription drugs every day for the rest of our lives. Luckily, there are natural supplements that are antihistamines!

It can be a life changer to find natural antihistamine supplements that are safe, effective and don’t require a prescription. I am not a doctor and cannot give medical advice. Check with your doctor and see if you can try these great natural antihistamine supplements.

5 Natural Supplements That Lower Histamine:

Quercetin-This is my #1 choice for a natural anti-histamine supplement. It is a natural bioflavanoid found in foods such as onions, garlic, apples, wine and tea. Querctin is an anti-oxidant. It functions similar to prescription cromolyn drugs which are mast and basal cell stabilizers. These drugs are used for asthma and allergies. https://www.sciencedirect.com/topics/neuroscience/quercetin

Vitamin C-This is a great supplement. If you have a sensitive stomach or digestion you may need a buffered vitamin C. I use Ester-C every day and love it.

Nettle-This might sound strange but the stinging nettle plant can bring great natural antihistamine benefits. I was slow to try this because it seemed counter-intuitive to use a potentially irritating plant but this stuff works.

Zinc-I discovered the anti-inflammatory benefits of zinc accidentally and then discovered it is also a natural antihistamine! Zinc also helps DAO Enzymes (below) break down histamine.

DAO Enzyme-DAO is Diamine Oxidase, an enzyme in the body that breaks down histamine. I have not yet tried this myself but DAO enzyme is the go-to supplement for treating histamine intolerance.

Recommended Supplement Brands to Lower Histamine

Recommended Quercetin Supplements for Histamine Control

Jarrow Formulas Quercetin is the brand I use. It gets nearly 300 perfect reviews on Amazon with customers proclaiming it their secret for fighting sinus infections, inflammation, mast cell activation syndrome, allergies, and even asthma. Grateful users report it helps with food and environmental allergies, lowering histamine release as well as common illness prevention and even prostate problems. They list many other unique benefits such as reducing reaction to poison ivy, sun exposure and treating psoriasis. Helping allergies is the most commonly cited use in hundreds of reviews.

Jarrow Formulas Quercetin uses an anhydrous form of quercetin which is supposed to be more effective than the dihydrate form which some other brands use. There are other forms of quercetin such as rutinoside which is poorly absorbed.

 

Now Foods Quercetin with Bromelain This is one of the best supplements for quercetin if you can have bromelain. Bromelain is a great anti-anflammatory and many quercetin supplements include bromelain. Bromelain is an enzyme found in pineapply. This supplement gets nearly 700 perfect reviews on Amazon and is an Amazon Choice product. Now Quercetin with Bromelain is very affordable as well and the Now Foods brand is known for high quality. I don’t take this brand since I am sensitive to bromelain but I have used Now brand supplements for years.

Recommended Vitamin C Supplements for Histamine Control

I use Ester-C with Citrus Bioflavanoids which has several advantages over regular vitamin C. Ester-C is buffered with calcium so it is not hard on the stomach like traditional vitamin C. Ester-C time releases vitamin C so one dose lasts up to 24 hours.

Recommended Nettle Supplements for Histamine Control

There are many brands of nettle supplements but those that use a freeze drying process are most effective. I use Solaray Freeze-Dried Nettle Capsules. When I ran out of these I really noticed how much worse I felt. Nettles have a definite anti-histamine affect and help control the body’s on/off switch for the inflammatory process as well.

Freeze drying preserves more of the active ingredients in the plant and also preserves the plant’s color and smell. I can see, smell and taste a huge difference between these freeze-dried nettle supplements and others that are not freeze dried. The freeze-dried SolarRay brand below has a fresh green color like a real plant whereas non freeze-dried versions are brown. These also have a very nice, fresh scent compared to other brands. They even taste good! The taste is fresh and plant like, rather than a dull supplement flavor. I will always get freeze-dried nettle from now on since I have seen the difference for myself. These are also more effective for me. I don’t notice much affect from other nettle supplements. When I ran out of these freeze-dried SolarRay capsules I felt much worse and knew I needed to reorder.

Recommended Zinc Supplements for Histamine Control

Zinc is a naturally occurring mineral that the human body requires just like magnesium and others. Zinc serves many functions in the body but for allergies it serves as an anti-histamine and anti-inflammatory. I accidentally discovered zinc helped me in this regard when I took Zicam for fighting common colds and noticed that my inflammation from bursitis was greatly improved. Whenever I took Zicam the bursitis swelling was down considerably. I looked it up and discovered that as well as fighting viruses like the common cold, zinc is a natural anti-inflammatory. When I started having severe allergies and histamine reactions I learned that zinc is also an anti-histamine.

Zinc also helps DAO enzymes break down histamine. Whether you are taking extra DAO as a supplement or not, adding zinc can help.

You can get zinc in many forms including tablets, capsules and liquid. I now use ionic liquid drops. (Note: Do not put these drops straight in your mouth). The drops can be added to any liquid such as a beverage. They don’t taste good but if you dilute them in a glass of juice or whatever you like to drink you should hardly notice them. I prefer the liquid since liquids are absorbed better than pills and it is easier to adjust the dose. Zinc can be hard on the stomach so make sure you take it with food.

I will be adding a longer post about zinc and link to it here. If you are interested in learning how and why Americans and many others are becoming more and more deficient in vitamins and minerals, here are some answers. Why Do You Need Extra Vitamins and Minerals?

Recommended DAO Supplements for Histamine Control

DAO (diamine oxidase) enzyme is an enzyme in the human body that metabolizes histamine. If you don’t have enough DAO enzyme you may end up with severe allergic reactions due to high levels of histamine. Some people are genetically prone to produce less DAO. Medications, diet, alcohol consumption and small intestinal bacteria overgrowth are some other causes of low DAO levels.  Supplementing with DAO enzyme supplements can alleviate some of theses symptoms. Here are some DAO supplements on Amazon to chose from.

Zinc helps DAO enzymes break down histamine so this is another reason supplementing with zinc may be beneficial.

Vitamin B-6 is another nutrient that helps DAO enzymes break down histamine.

Can Supplements Replace Conventional Antihistamines?

You may be able to use supplements in combination with antihistamines to get better results for allergies and other histamine problems. Of course you should talk to your doctor about doing this. I am not a doctor and cannot give medical advice. I am currently taking Allegra and supplements and hope to be able to get away from antihistamines eventually and just use the supplements. They definitely help. I can tell I am so much worse when I don’t take the supplements. Especially the nettle and quercetin. I have yet to try DAO enzyme supplements. I suspect the addition of DAO might be enough to push me over the edge where I don’t need conventional antihistamines anymore. Alternately, I may be able to stop taking antihistamines in the winter months when there is no pollen in the air. I will update this post with my results.

Note: I am not a doctor or medical professional. These recommendations are based on personal experience and research. Consult a doctor for a diagnosis and treatment options. 

Jessica

NutrientCures only offers honest reviews and never recommends a product we wouldn’t use ourselves everyday.  NutrientCures makes use of affiliate relationships with merchants such as Amazon Associates for monetization. This means when you click on links to various merchants on this site and make a purchase, this can result in a small commission that is credited to this site.

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41 Comments

  1. Shan

    I really enjoyed reading your article and learned some new facts too! As an herbalist and an allergy sufferer, I thought I knew just about everything there was to know about natural supplements to combat allergies. 

    I am super excited to learn about quercetin. I am to the point that I am off the daily prescription medications I previously took but there are still some days my allergy symptoms get the best of me. With the help of quercetin, I may be able to kick my allergy symptoms once and for all! I can’t wait to try it! 

    Thanks so much for the great suggestions!

    Reply
    1. admin

      Hello Shan,

      I didn’t know much about quercetin until this year but as my allergies get worse every year I had to find something more effective. Quercetin is great. I hope it words for you too.

      Thank you for stopping by and sharing your comments,

      Jessica

      Reply
  2. Briana

    I never had allergies growing up, but a few years ago we moved from California to Texas and the change of environment caused some serious allergy issues. I try to avoid medications if possible so natural solutions are great. My son also has allergies so at his next appointment I will be talking to his pediatrician about using some of these more natural methods instead of Benadryl. Thanks for a great article. 

    Reply
    1. admin

      Hello Briana,

      I am like you. I developed allergies later and was shocked. They are BAD. I got hives for the first time this spring but they have been getting worse for several years. I could hardly go to work for the whole pollen season. I was desperate to find a solution. 

      I hope these supplements help your son too!

      Thanks for your comments,

      Jessica

      Reply
  3. Dane

    Wow thanks for this really educating post. I never knew these supplements could lower histamine all these while. My son son allergy have been a very serious issue for quite some time now. Whe have lived in an estate where he hardly gets allergic reaction but since we changed environment he he gets this attacks very often, we have tried some drugs which doesntl’t seem to be effective. I’ll see to him taking these supplements and hopefully it will do the magic. 

    Reply
    1. admin

      Hello Dane, 

      I hope you have found some relief for your son. Is he trying some of these supplements now?

      Jessica

      Reply
  4. Jim

    Hi Jessica. I’ve been checking out the web to find information on allergies and stumbled across your blog. I have developed all sorts of allergies of late. Its something I’ve never had an issue with before. Some years back I started to suffer esophageal pains that got pretty severe over time. My doctor placed me on a product called Nexium, which seemed to help and I thought no more about it. Then, about a year ago I started suffering from various allergies. They can be brought on by grass clippings, dust and even cold weather. After trying to find out what the catalyst might have been for these allergies for some time, I recently found out that Nexium can be the catalyst. I have tried several medicines that haven’t worked. That’s why I am excited about your article. I will now try out some of the natural remedies that you have highlighted. I know that my wife will like the fact that nettle can be part of the remedy, as she has used this plant for other reasons for many years. Thank you for you excellent information on natural supplements for Histamine control. Jim

    Reply
    1. admin

      Hello Jim,

      I was pretty amazed at how much I liked the freeze dried nettle. It actually smells good and works well. I am sorry you have so many allergies. I understand. I never had any (that I knew about) when I was younger but I am getting more and more now. That is why I went looking for better treatments since I didn’t want to be stuck on antihistamines every day for the rest of my life!

      I hope you try some of these and they work for you.

      Thanks for your comments,

      Jessica

      Reply
  5. gr8megawinner

    What supplements lower histamine? They work like anti-histamine such as  Nettle, DAO Enzyme, Zinc, and Quercetin. My daughter uses Claritin but I learned about Bendryl and Allegra. The supplements that lower Histamine such as Jarrow Formula Quercetin, Ester C, Solaray. It is good to know some meds for allergy or Histamine intolerance,. This makes me more confident since members of my family have issues with this.

    Reply
  6. Henderson

    Hello Jessica, I am happy to read your post again. Very many people have allergies and there are only a very few that dont. Today, I have learnt about histamine and the supplements that can be used to reduce the effects of allergies. You have quite a broad knowledge of the subject matter. I think I will be getting some of this products and I’m happy you said they can be used together. I will however visit my doctor to determine if its good for me to get on. Educative post here!

    Reply
    1. admin

      Hello Henderson,

      I hope you can try these supplements and they work well for you.

      Jessica

      Reply
  7. Cathy Allen

    Wow! Plenty of suggestions. I have constant skin issues; I itch nonstop, and I have the sores all over my arms and back to prove it. I’ve tried both OTC and prescribed creams, ointments, oils, and pills. Aloe, Vaseline, coconut oil, and argan oil are my go-to’s. 

    Your article gave me some new ideas. I’m going to look into these supplements. Argan oil is great for spot treatment; it clears up dermatitis as well as, if not better than, prescription topicals. Your research is the first I’ve seen of it’s kind. Maybe because I haven’t gone looking for it, before. 🙂

    Reply
    1. admin

      I hope some of these supplements can help you. Zinc really helps with itching. I bought my husband a clear, natural zinc sunscreen wondering if it would work as a good itch killing topical. It seems to help.He has bad itching on his arms that comes and goes but appears to be psoriasis.  

      Zinc is the common ingredient in most anti-dandruff shampoos so I wondered why there are not more skin lotions with zinc! 

      Thanks for stopping by and sharing your comments. 

      Jessica

      Reply
  8. Virendra

    Thank you for sharing this information! I was wondering now, do you think these supplements can also reduce the symptoms of hay fever? I have a friend who’s always suffering a lot when spring is coming and I’d like to forward this post to him. And I’m more and more into natural and biological supplements, which one do you think is suitable for that? It’s not so clear in the description how they are produced.

    Reply
    1. admin

      Hello Virendra,

      Yes, hay fever is an allergic response and this is exactly what these supplements are for. All of these supplements are natural and either plant, mineral or vitamin based. You could try any of them. 

      Thank you for stopping by,

      Jessica

      Reply
  9. Jenifer

    Hi Jessica!  Thanks so much for sharing this article.

    My son suffered from allergies when he was younger (that was about 25 years ago), so my background on using supplements to treat allergies is way outdated!

    I was very surprised to learn about Vitamin C and Nettle being used to lower histamine!  I wish I would have had this information back then.

    I am bookmarking your site and plan to share with my son.  He has blessed me with 3 grandbabies; 1 boy, Daniel and 2 girls, Abbey and Jessie.  Daniel was born with allergies just like his dad.  I’m sure he will find your website helpful as well.

    Thanks again,

    Jen S.

    Reply
    1. admin

      Hello Jen,

      I hope your son can use this information to help your grandson with his allergies. I would certainly prefer to use these supplements for kids rather than prescription drugs. 

      Thanks for stopping by,

      Jessica

      Reply
  10. Nate Stone

    Hi Jessica,

    Interesting article, I suffer really badly from hay fever. Interestingly, a lot of the supplements that you recommend I already take as their anti inflammatory properties make them an effective way to increase testosterone production (my area of expertise). Prior to taking these supplements my hay fever was considerably worse so they definitely help, I still suffer a little bit so I’ll look at trying nettles as well, as I prefer natural remedies where possible!

    Reply
    1. admin

      Hello Nate,

      I hope you can try the nettles and they help your hay fever. I recommend you get freeze-dried nettles if you try them. They seem to work much better. 

      Thank you for stopping by,

      Jessica

      Reply
  11. Edward

    Wow very interesting. I never knew that about histamines and allergies. I’m glad there are natural supplements you can take instead of taking prescription drugs. I have a good amount of garlic and apples in my diet so I guess that’s getting me The first one. I will have to look into zinc as an anti-inflammatory. I definitely have more Inflammation than histamines.

    Nettles also sound interesting. I will have to look more into this and see if I need to include an antihistamine in my nutrition program. Thanks!

    Reply
    1. admin

      Nettles help with inflammation as well. I hope you can try zinc and nettles and they make you feel better!

      Thanks for stopping by,

      Jessica

      Reply
  12. Twack Romero

    Two points to address that your excellent article has bought up. I’d never made the ‘connection’, before reading your article, that there was actually a ‘histermine’, I’d just always heard the term ‘anti-histermine’ and associated it with allergy sympton reduction. Love it when I learn something new.

    Very ocassionally I might suffer with a few sniffles but it’s my wife that really struggles with ‘streaming’ eyes and nose. As we are both always looking for natural alternatives to many things, this article was a breath of fresh air. Zinc was the outright winner for us. As well as being hit by Hay fever my better half is also allergic to Aspirin and Ibuprofen, so seeing as Zinc has anti-inflammatory properties, it has double the value. Having the liquid form in a flavoured drink looks to be a well-advised option.

    Reply
    1. admin

      I am glad this was useful for you Twack. 

      I hope your wife gets some relief and zinc works for both of you.

      Thanks for stopping by.

      Jessica

      Reply
  13. Abayomi

    Excellent article,and informative,I was excited reading through your post,I’ve really learned a lot,the supplements are very potent in tackling the histamine problems.the conventional antihistamines is still needed,both can be used together for efficient result.The supplement mentioned is active,but must be used whenever there is symptom of allergy,I appreciate your effort  for writing this,very helpful and educative,thank you.

    Reply
    1. admin

      Thank you for stopping by Abayomi.  I am glad you found this useful. 

      Jessica

      Reply
  14. Peter

    Will supplements help with tree nut allergies? My son has an allergy to tree nuts and I have been doing some research which is how I found your site. If there is something we can do to alleviate his (& our anxiety) would be beneficial.

    It is great to know there are so many alternatives to constantly using medication. I will read up some more and speak to our GP and ascertain whether these will be suitable. Thanks for your post, its been a revelation.

    Reply
    1. admin

      Hello Peter,

      I know nut allergies can be very serious so if your son has serious allergies I would not suggest a supplement if he should just stay away from nuts entirely. For a milder allergy I would think these supplements could help. I would ask a doctor if he could try them. 

      Thank you,

      Jessica

      Reply
  15. I think Ill try the Quercitin

    I THINK I’m going to try the quercetin. Benadryl is like the date rape drug on me. It will knock two days off my life with drowsiness. great article I’ve always heard zinc may not be so good us, but I think I will give the Quercetin. Really good article.

    Reply
    1. Jessica (Post author)

      Thank you. I am glad you might try quercetin. I am curious what you heard about zinc?

      Jessica

      Reply
  16. Steve

    This is a really cool article and I am glad to have read it. My son deals with seasonal allergies and my family always likes to go the natural route as often as we possibly can. I would love to try some of these out, specifically for allergies, as I have taken the Ester C you recommended before. 

    I am wondering if you know if any of these are recommended safe for children, as my son seems to be the one in our family who is most affected. 

    Thanks so much for the information and product suggestions!

    Reply
    1. admin

      Hello Steve,

      I believe all of these can be taken by kids. Here is an article about natural anti-histamine supplements for kids which lists Vit C, Quercetin and Nettle among others. 

      https://www.healthychild.com/natural-allergy-medicine-for-kids/

      Quercetin is not safe during pregnancy but is fine for kids to take. Ester C makes an Ester C for Kids version with a lower dosage of Vit C. There are DAO products for kids as well such as D-Hist Jr.

      Zinc can be used to lower allergies, asthma and ADHD in kids. I am not a doctor and cannot recommend specific doses however. 

      I hope you can try some of these and they help your son!

      Jessica

      Reply
  17. Selenity Jade

    Hi, Jessica!  This was a very informative post!  I actually had no idea that some supplements could help lower histamines like antihistamines do!  I guess it just didn’t occur to me since I don’t have major allergies.  Oddly enough, I had allergies when I was in Kentucky, the entire 7 months I was there.  I had to take Zyrtec every day for those 7 months or I would be sneezing my head off.  Yet, I don’t have to take antihistamines regularly anywhere else.  Kind of odd, no?

    I did learn something interesting from a pharmacist though!  If you have a cold and are sneezing?  Antihistamines, even though it’s not caused by an allergy.  Does this work?  I’m not sure.  My colds aren’t usually sneezing fits.  ^_^;  Might be interesting to see if this is the case with supplements as well!

    Thanks for the information!

    Reply
    1. admin

      Hello Selenity Jade,

      I am not surprised you had the allergies in Kentucky. Was it during the time last year when they had the incredibly high levels of pollen? I heard it was record breaking and my co-worker’s wife broke out in rashes and hives while down there. 

      It makes sense that an antihistamine would help with sneezing during a cold. The sneezing part of a cold is similar to an allergic reaction where the nasal passages get inflamed and irritated. 

      Thanks so much for stopping by!

      Jessica

      Reply
  18. Rob S.

    Quercetin is fairly new to me but I have heard of it before. I don’t suffer from allergies or at least I didn’t until I moved south.
    But my daughter has issues with allergies and I’m trying to get her to try supplements.
    Vitamin C is absolutely awesome for your health and I take a lot when I have a cold.
    Zinc is also beneficial and I try and get it through foods first before turning to a supplement.
    But the bottom line is to do whatever works for relieving the suffering, right?

    Reply
    1. admin

      Hello Rob, 

      Yes. It is great to get these nutrients through food but if we are sick we can use more. If we are prone to a certain problem like allergies we probably need more as well. Some people have genetic predisposition for allergies and these people would likely benefit from extra supplements to help control histamine levels. 

      I had not tried quercetin before I started getting severe allergies recently. The problem with allergies is that they can develop seemingly out of the blue. You may go for decades without them and then they appear. 

      Thanks for stopping by and for your comments,

      Jessica

      Reply
  19. SeunJeremiah

    Thanks for this informative post having a histamine intolerance can be very frustrating because the symptoms often feel like they come out of nowhere. Trust me, I understand! I had a histamine intolerance myself at one point, and I kept getting these terrible headaches seemingly out of the blue, I’m so happy I came across this post sooner than later. I consulting my doctor to know which of these supplements will be good for me. 

    Reply
    1. admin

      Hello,

      I am sorry you have histamine problems but I know how you feel. Mine were so bad they were affecting my vision this spring! I was scared to death I would go blind in one eye. It seems to have been related to the histamine effect however and is getting better! This is pretty amazing. I had no idea histamine could harm vision.

      Thanks,

      Jessica

      Reply
  20. Jordan Smith

    My little experience with DAO Supplements was magical. I have dealt with a full body itch for years, at first I thought it was caused by a food allergy. But after taking out almost everything out of my diet, I was never been able to get a bead on exactly what could be the cause. Then a Doctor (friend) to;d me it was food and environmental allergies. Such a hard thing to pin point. He suggested I take a DAO Supplements, and that was it. I found it hard to sleep at night due to the heat and itching of my skin. After taking the supplement for a few months the itching completely stopped. It was a life saver.

    Nice write-up Jessica!

    Regards.

    Reply
    1. admin

      I am so glad DAO worked for you! It is amazing how effective supplements can be if we know how to use them correctly and for the right conditions. 

      Thanks for sharing your experience with DAO.

      Jessica

      Reply
  21. Karin

    Thanks for the review of these products! I have been having a terrible allergic reaction to something in my environment with face and lip swelling as well as hives and other itching in my hands and legs. It has been horrible and life-threatening with my tongue even swelling up. I will be checking out some of these products after I consult with my physician to see if any of them can help me!

    Reply
    1. Jessica (Post author)

      I hope one of them can help you Karin. I just had a scary reaction myself last weekend. My mouth was tingling and my throat went numb. The tingling lasted for 3 days! I am still not sure what I was allergic to. I was eating ice cream made from almond milk so it might be almonds but I have had other kinds of almond milk and been ok. If you have allergies to pollen you can be allergic to certain foods like tree nuts and I have developed serious pollen allergies recently.

      It is scary not knowing when and what might trigger a reaction.

      Thanks for stopping by and commenting.

      Jessica

      Reply

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